Preheat oven to 350°F. Spray a 9x13-inch baking dish with cooking spray and set aside.
In a large skillet over medium-high heat, cook ground beef and chopped onion for 8-10 minutes, breaking up the meat into small crumbles. Cook until no pink remains and onions are soft and translucent. Drain excess grease.
Reduce heat to medium-low. Add cream of chicken soup, milk, diced green chilies (with liquid), oregano, garlic salt, and black pepper to the skillet. Stir well to combine.
Let the mixture simmer gently for 2-3 minutes, stirring occasionally.
Add 1 cup of shredded cheese to the beef mixture. Stir until completely melted. Remove from heat.
Spread half of the tortilla chips across the bottom of the prepared baking dish, breaking large chips to fill gaps.
Spoon half of the beef mixture over the chips and spread evenly.
Add another layer of tortilla chips, then top with remaining beef mixture, spreading evenly.
Sprinkle the remaining 2 cups of shredded cheese over the top, covering to the edges.
Bake uncovered for 30 minutes, until cheese is melted, bubbly, and golden brown in spots.
Remove from oven and let rest for 5 minutes before serving.