The best meatloaf recipe featuring milk-soaked breadcrumbs and a sweet ketchup glaze. This foolproof method creates incredibly tender, juicy results every time.
Fat content is crucial: Use 80/20 ground beef for optimal moisture and tenderness
Test seasoning: Cook a small patty to taste and adjust seasonings before forming loaf
Temperature matters: Use instant-read thermometer and don't exceed 165°F to prevent drying
Storage: Refrigerate up to 4 days or freeze up to 4 months
Make-ahead: Meat mixture can be prepared 24 hours ahead and refrigerated
Substitutions: Ground turkey (85/15) can substitute beef; add extra egg for binding
Mini loaves: Divide into 6-8 portions in muffin tin, reduce cooking time to 25-30 minutes